SCHEMBL19003538

SCHEMBL19003538

CCCCCC(CCC)c1ccccc1C#N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.41
CYSLTR2 Q9NS75 2/20 0.40
CYSLTR1 Q9Y271 2/20 0.40
TSHR P16473 3/20 0.39
ALDH1A1 P00352 4/20 0.37
GRM2 Q14416 1/20 0.37
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HPGD P15428 2/20 0.33
NPC1 O15118 1/20 0.33
CASP3 P42574 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
SENP8 Q96LD8 1/20 0.33
SENP7 Q9BQF6 1/20 0.33
SENP6 Q9GZR1 1/20 0.33
CSNK1E P49674 1/20 0.32
NR1I2 O75469 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30595388 0.90 L3MBTL1 (0.44) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
Hydrochloric Acid SCHEMBL29882504 0.89 L3MBTL1 (0.43) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL5174494 0.85 L3MBTL1 (0.38) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL17818518 0.85 CYSLTR2 (0.36) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL19003527 0.85 L3MBTL1 (0.40) L3MBTL1TSHRALDH1A1GRM2CYP2C9
SCHEMBL6678913 0.82 L3MBTL1 (0.42) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL31159072 0.82 L3MBTL1 (0.42) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL6686091 0.81 L3MBTL1 (0.41) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL29788766 0.81 L3MBTL1 (0.41) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1
SCHEMBL29788776 0.81 L3MBTL1 (0.41) L3MBTL1CYSLTR2CYSLTR1TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2938344-B1 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES MERCK SHARP & DOHME (US) 2017-06-21 EP disclosed