Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24759946 | 0.90 | MEN1 (0.34) | — | |
| SCHEMBL18948527 | 0.85 | MEN1 (0.35) | KDM4ELMNA | |
| SCHEMBL24759748 | 0.84 | MEN1 (0.35) | KDM4E | |
| SCHEMBL20229863 | 0.82 | KDM4E (0.31) | KDM4E | |
| SCHEMBL20229630 | 0.79 | NR1I2 (0.34) | — | |
| SCHEMBL20621385 | 0.76 | LMNA (0.32) | KDM4ELMNAHTTSMN1; SMN2NR2F2 | |
| SCHEMBL24759945 | 0.74 | MEN1 (0.35) | KDM4ELMNAHTTSMN1; SMN2NR2F2 | |
| SCHEMBL2757601 | 0.72 | KDM5B (0.38) | KDM4EGAALMNASMN1; SMN2NR2F2 | |
| SCHEMBL23467866 | 0.71 | KDM4E (0.33) | KDM4EGAALMNAHTTSMN1; SMN2 | |
| SCHEMBL19902440 | 0.68 | KDM4E (0.33) | KDM4EGAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |