Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15858019 | 1.00 | MAPT (0.42) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL17897246 | 0.89 | MAPT (0.41) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL17897235 | 0.83 | MAPT (0.43) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL15858970 | 0.83 | MAPT (0.43) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL15857994 | 0.83 | MAPT (0.43) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL19003730 | 0.83 | MAPT (0.43) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL17897293 | 0.79 | MAPT (0.40) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL17897303 | 0.79 | MAPT (0.40) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL17897236 | 0.79 | MAPT (0.40) | MAPTLMNAALDH1A1MAPK1HTT | |
| SCHEMBL18948442 | 0.79 | ALDH1A1 (0.41) | MAPTLMNAALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |