Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27372185 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTLMNAGFERNPSR1 | |
| SCHEMBL2610122 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTLMNAGFERNPSR1 | |
| SCHEMBL15858036 | 0.84 | HRH3 (0.48) | SMN1; SMN2LMNAMAPK1TP53HRH3 | |
| SCHEMBL14922270 | 0.84 | DRD2 (0.50) | MAPTLMNAMAPK1ALDH1A1TP53 | |
| SCHEMBL15858008 | 0.84 | HRH3 (0.48) | SMN1; SMN2LMNAMAPK1TP53HRH3 | |
| SCHEMBL21590190 | 0.84 | HRH3 (0.51) | SMN1; SMN2MAPTTDP1MAPK1POLB | |
| SCHEMBL21590260 | 0.84 | HRH3 (0.51) | SMN1; SMN2MAPTTDP1MAPK1POLB | |
| SCHEMBL21590149 | 0.84 | HRH3 (0.51) | SMN1; SMN2MAPTTDP1MAPK1POLB | |
| SCHEMBL20884848 | 0.84 | KDM4E (0.52) | SMN1; SMN2MAPTLMNAGFERNPSR1 | |
| SCHEMBL19003614 | 0.84 | HRH3 (0.48) | SMN1; SMN2LMNAMAPK1TP53HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105363-A1 | PYRIDONE AND PYRIMIDINONE INHIBITORS OF HEMATOPOIETIC PROGENITOR KINASE 1 | CURADEV PHARMA LTD (GB) | 2024-05-23 | — | — | WO | disclosed |
| EP-2938344-B1 | PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME (US) | 2017-06-21 | — | — | EP | disclosed |