Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.40 |
| ▸ | F3 | P13726 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.37 |
| ▸ | ADA | P00813 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908031 | 0.89 | MEN1 (0.41) | MEN1KMT2ABACE1BACE2F2 | |
| SCHEMBL1902822 | 0.89 | BACE1 (0.40) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1905848 | 0.89 | BACE1 (0.40) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1907931 | 0.85 | BACE1 (0.40) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1902876 | 0.85 | BACE1 (0.40) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1902350 | 0.85 | MASP2 (0.41) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1908077 | 0.85 | F3 (0.38) | MEN1KMT2ABACE1BACE2F2 | |
| SCHEMBL1907648 | 0.84 | BACE1 (0.44) | MASP2BACE1BACE2F2PRSS1 | |
| SCHEMBL1902346 | 0.84 | BACE1 (0.44) | MASP2MEN1KMT2ABACE1BACE2 | |
| SCHEMBL1906781 | 0.82 | BACE1 (0.42) | MASP2BACE1BACE2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |