Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902623 | 1.00 | MTNR1A (0.43) | MTNR1AMTNR1BPTGDR2LMNATDP1 | |
| SCHEMBL1902050 | 1.00 | MTNR1A (0.43) | MTNR1AMTNR1BPTGDR2LMNATDP1 | |
| SCHEMBL1902048 | 1.00 | MTNR1A (0.43) | MTNR1AMTNR1BPTGDR2LMNATDP1 | |
| SCHEMBL1900547 | 1.00 | MTNR1A (0.43) | MTNR1AMTNR1BPTGDR2LMNATDP1 | |
| SCHEMBL1902813 | 0.93 | MTNR1A (0.50) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL2492406 | 0.93 | MTNR1A (0.50) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL1900922 | 0.88 | MTNR1A (0.42) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL1904612 | 0.88 | MTNR1A (0.42) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL1900925 | 0.88 | MTNR1A (0.42) | MTNR1AMTNR1BPTGDR2 | |
| SCHEMBL1899886 | 0.87 | PTGDR2 (0.43) | MTNR1AMTNR1BPTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |