Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28886725 | 0.83 | PDK2 (0.47) | RETTTKGPR119PDK2LRRK2 | |
| SCHEMBL12461826 | 0.82 | RET (0.55) | RETTTK | |
| SCHEMBL20157515 | 0.82 | PDK2 (0.64) | PDK2NR1H2 | |
| SCHEMBL19005627 | 0.81 | P2RX7 (0.58) | RETTTKPDK2PARP1NR1H2 | |
| SCHEMBL10095021 | 0.79 | NR1H2 (0.47) | PDK2NR1H2 | |
| SCHEMBL16027918 | 0.77 | P2RX7 (0.59) | GPR119 | |
| SCHEMBL30552179 | 0.76 | P2RX7 (0.56) | — | |
| SCHEMBL26113816 | 0.76 | P2RX7 (0.56) | — | |
| SCHEMBL109572 | 0.75 | TACR3 (0.41) | TTKPDK2NR1H2 | |
| SCHEMBL30980030 | 0.75 | P2RX7 (0.56) | GPR119PDK2PARP1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017101796-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2017-06-22 | — | — | WO | disclosed |