Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23280414 | 0.69 | HPGD (0.41) | HPGDHTTPKMPHGDHKDM4E | |
| SCHEMBL23095875 | 0.67 | KMT2A (0.41) | HPGDHTTPHGDHALDH1A1KMT2A | |
| SCHEMBL30073547 | 0.65 | HSP90AA1 (0.34) | HPGDHTTALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL14037694 | 0.64 | HPGD (0.45) | HPGDHTTPKMPHGDHALDH1A1 | |
| SCHEMBL3376203 | 0.64 | HPGD (0.45) | HPGDHTTPKMPHGDHTSHR | |
| SCHEMBL10720943 | 0.63 | PHGDH (0.81) | HPGDHTTPKMPHGDHKDM4E | |
| SCHEMBL22353364 | 0.62 | PHGDH (0.44) | HPGDHTTPKMPHGDHKDM4E | |
| SCHEMBL786679 | 0.61 | SMN1; SMN2 (0.59) | HPGDHTTPKMTSHRKMT2A | |
| SCHEMBL28693899 | 0.61 | HPGD (0.53) | HPGDHTTPKMPHGDHTSHR | |
| SCHEMBL7121916 | 0.60 | SMN1; SMN2 (0.77) | HPGDHTTPKMALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181554-A1 | QUINAZOLINE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |