Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23095872 | 0.79 | ALDH1A1 (0.40) | HPGDTSHRHTTPHGDHGAA | |
| SCHEMBL20221039 | 0.76 | PTPN7 (0.38) | TSHRSMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL23048514 | 0.73 | GABRR1 (0.31) | — | |
| SCHEMBL1353549 | 0.73 | GABRR1 (0.31) | — | |
| SCHEMBL30073547 | 0.69 | HSP90AA1 (0.34) | HPGDHTTHSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL20327601 | 0.69 | ALDH1A1 (0.38) | HPGDTSHRHTTGAASMN1; SMN2 | |
| SCHEMBL19006943 | 0.69 | HPGD (0.41) | HPGDTSHRHTTHSP90AA1HSP90AB1 | |
| SCHEMBL23280320 | 0.67 | ALDH1A1 (0.33) | TSHRGAAALDH1A1POLBKMT2A | |
| SCHEMBL13149373 | 0.66 | ALDH1A1 (0.41) | HPGDHTTGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL23095875 | 0.66 | KMT2A (0.41) | HPGDHTTHSP90AA1HSP90AB1PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189041-B1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY LTD (AU) | 2021-04-28 | — | — | EP | disclosed |