Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 9/20 | 0.72 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.72 |
| ▸ | EGFR | P00533 | 9/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.65 |
| ▸ | FLT1 | P17948 | 6/20 | 0.65 |
| ▸ | FLT4 | P35916 | 6/20 | 0.65 |
| ▸ | RET | P07949 | 3/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.65 |
| ▸ | TEK | Q02763 | 2/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.65 |
| ▸ | KIF5B | P33176 | 2/20 | 0.65 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | STK10 | O94804 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520370 | 0.90 | KDR (0.79) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL18211400 | 0.88 | EGFR (0.82) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL22592730 | 0.87 | KDR (0.75) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL19220787 | 0.85 | EGFR (0.81) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL1791359 | 0.84 | EPHA2 (1.00) | KDREPHA2EPHB4EGFRERBB2 | |
| SCHEMBL19154592 | 0.80 | EGFR (0.84) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL1612820 | 0.79 | KDR (0.84) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL31319937 | 0.79 | KDR (0.84) | KDREPHA2EPHB4EGFRFGFR1 | |
| Vandetanib SCHEMBL9044 | 0.79 | EGFR (1.00) | KDREPHA2EPHB4EGFRFGFR1 | |
| Vandetanib SCHEMBL29352879 | 0.79 | EGFR (1.00) | KDREPHA2EPHB4EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181554-A1 | QUINAZOLINE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |