Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.67 |
| ▸ | EGFR | P00533 | 14/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | KIF5B | P33176 | 2/20 | 0.67 |
| ▸ | FLT1 | P17948 | 12/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 11/20 | 0.55 |
| ▸ | FLT4 | P35916 | 10/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17520325 | 0.87 | KDR (0.77) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL17520351 | 0.86 | KDR (0.78) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL19006973 | 0.81 | EGFR (0.76) | KDREGFRFLT4PDGFRBTEK | |
| SCHEMBL5864525 | 0.81 | KDR (1.00) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL19006871 | 0.80 | KDR (0.61) | KDREGFRRETKIF5BFLT1 | |
| Hydrochloric Acid SCHEMBL7864775 | 0.80 | KDR (0.98) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL5448866 | 0.78 | KDR (0.73) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL19220775 | 0.78 | RET (0.64) | KDREGFRRETKIF5BFLT1 | |
| SCHEMBL19006858 | 0.78 | KDR (0.87) | KDREGFRRETKIF5BFLT1 | |
| Hydrochloric Acid SCHEMBL5453290 | 0.78 | KDR (0.71) | KDREGFRRETKIF5BFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181554-A1 | QUINAZOLINE DERIVATIVE | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2017-06-21 | — | — | EP | disclosed |