⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597218 | 1.00 | — | — | |
| SCHEMBL2701677 | 0.76 | — | — | |
| SCHEMBL5957000 | 0.76 | — | — | |
| SCHEMBL176 | 0.71 | — | — | |
| SCHEMBL19008050 | 0.71 | — | — | |
| SCHEMBL406091 | 0.64 | — | — | |
| SCHEMBL14350852 | 0.64 | — | — | |
| SCHEMBL10348306 | 0.64 | — | — | |
| SCHEMBL13497566 | 0.64 | — | — | |
| SCHEMBL2572328 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174695-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-06-22 | — | — | US | disclosed |