Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29669015 | 0.82 | SCN9A (0.59) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL20238716 | 0.82 | SCN9A (0.59) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL1094279 | 0.80 | SCN9A (0.57) | SCN9ASCN5A | |
| SCHEMBL20096109 | 0.80 | SCN5A (0.62) | SCN5ASCN1ASCN8A | |
| SCHEMBL22593001 | 0.79 | SCN9A (0.64) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL20449318 | 0.79 | SCN5A (0.54) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL19001194 | 0.78 | SCN9A (0.62) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL30479367 | 0.77 | SCN9A (0.55) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL22089147 | 0.77 | SCN9A (0.67) | SCN9ASCN5ACYP3A4SCN1ASCN8A | |
| SCHEMBL20449533 | 0.77 | SCN9A (0.54) | SCN9ASCN5ACYP3A4SCN1ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106226-A1 | HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |