Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16382698 | 0.86 | BTK (0.50) | BTKPDPK1JAK2MAP3K5SIRT3 | |
| SCHEMBL16382703 | 0.83 | BTK (0.45) | BTKPDPK1JAK2MAP3K5 | |
| SCHEMBL9936768 | 0.77 | BTK (0.42) | BTKPDPK1MAP3K5ALDH1A1ATM | |
| SCHEMBL16382684 | 0.77 | ALDH1A1 (0.40) | BTKALDH1A1ATM | |
| SCHEMBL17699610 | 0.75 | BTK (0.50) | BTKPDPK1JAK2MAP3K5SIRT3 | |
| SCHEMBL7609237 | 0.72 | NR4A2 (0.36) | BTKJAK2 | |
| SCHEMBL28337895 | 0.69 | BTK (0.53) | BTK | |
| SCHEMBL16382696 | 0.69 | BTK (0.55) | BTKPDPK1 | |
| SCHEMBL27614341 | 0.69 | POLB (0.48) | BTKJAK2SIRT3TDP1BRD4 | |
| Hydrochloric Acid SCHEMBL27784477 | 0.67 | POLB (0.46) | BTKJAK2SIRT3TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170174624-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | ABBVIE INC. (US) | 2017-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174624-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | BTK, SYK, MYD88 | BTK 1/4885PDPK1 601/4885JAK2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.