⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122402 | 0.81 | — | — | |
| SCHEMBL5458009 | 0.72 | — | — | |
| SCHEMBL27423110 | 0.70 | — | — | |
| SCHEMBL4039262 | 0.68 | — | — | |
| SCHEMBL4048541 | 0.68 | — | — | |
| SCHEMBL6373455 | 0.67 | — | — | |
| SCHEMBL15333339 | 0.67 | — | — | |
| SCHEMBL15333759 | 0.67 | — | — | |
| SCHEMBL9481280 | 0.67 | — | — | |
| SCHEMBL15333344 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8652468-B2 | Methods of binding TNF-α using anti-TNF-α antibody fragment-polymer conjugates | GENENTECH, INC. (US) | 2014-02-18 | — | — | US | disclosed |
| US-20130084302-A1 | Methods of binding TNF-alpha using Anti-TNF-alpha antibody fragment-polymer conjugates | HSEI VANESSA (US) | 2013-04-04 | — | — | US | disclosed |
| US-8147830-B2 | Antibody fragment-polymer conjugates and uses of same | GENENTECH, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110104185-A1 | ANTIBODY FRAGMENT-POLYMER CONJUGATES AND USES OF SAME | HSEI VANESSA | 2011-05-05 | — | — | US | disclosed |
| US-7842789-B2 | Antibody fragment-polymer conjugates and uses of same | GENENTECH, INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090098147-A1 | Antibody fragment-polymer conjugates and uses of same | HSEI VANESSA | 2009-04-16 | — | — | US | disclosed |
| US-7507405-B2 | Antibody fragment-polymer conjugates and uses of same | GENENTECH, INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7214776-B2 | Antibody fragment-polymer conjugates and uses of same | GENENTECH, INC. (US) | 2007-05-08 | — | — | US | disclosed |
| US-20070048219-A1 | Antibody fragment-polymer conjugates and uses of same | HSEI VANESSA | 2007-03-01 | — | — | US | disclosed |
| US-7122636-B1 | Antibody fragment-polymer conjugates and uses of same | GENENTECH, INC. (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1415998-A2 | Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies | Genentech, Inc. (US) | 2004-05-06 | — | — | EP | disclosed |
| EP-0968291-B1 | ANTIBODY FRAGMENT-POLYMER CONJUGATES | GENENTECH INC (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030021790-A1 | Antibody fragment-polymer conjugates and humanized anti-IL-8 monoclonal antibodies | GENENTECH, INC. | 2003-01-30 | — | — | US | disclosed |
| US-6468532-B1 | F(AB')2 COMPRISING ANTIGEN BINDING SITE COVALENTLY BONDED TO POLYETHYLENE GLYCOL AT CYSTEINE RESIDUE; ADULT RESPIRATORY DISTRESS SYNDROME | GENENTECH, INC. | 2002-10-22 | — | — | US | disclosed |
| US-6458355-B1 | Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates | GENENTECH, INC. | 2002-10-01 | — | — | US | disclosed |
| US-6133426-A | POLYPEPTIDE HAVING LIGHT CHAIN AMINO ACID SEQUENCE OF SPECIFIC COMPLEMENTARY DETERMINING REGIONS OR A SPECIFIC HEAVY CHAIN AMINO ACID SEQUENCE; FOR DIAGNOSIS OF INFLAMMATORY CONDITIONS; ANTIINFLAMMATORY AGENTS | GENENTECH, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6025158-A | FOR DIAGNOSIS OF AND ANTIINFLAMMATORY AGENTS FOR ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, MULTIPLE ORGAN FAILURE AND OTHER INFLAMMATORY DISEASES | GENENTECH, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0968291-A2 | ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES | Genentech, Inc. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1999037779-A1 | ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES AND USES OF SAME | GENENTECH, INC. (US) | 1999-07-29 | — | — | WO | disclosed |
| WO-1998037200-A2 | ANTIBODY FRAGMENT-POLYMER CONJUGATES AND HUMANIZED ANTI-IL-8 MONOCLONAL ANTIBODIES | GENENTECH, INC. (US) | 1998-08-27 | — | — | WO | disclosed |