Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902995 | 0.92 | HRH1 (0.45) | HRH1PTGDR2SMN1; SMN2KDM4ENPY1R | |
| SCHEMBL18043823 | 0.89 | PTGDR2 (0.46) | HRH1PTGDR2SMN1; SMN2NPC1MAPT | |
| SCHEMBL1894331 | 0.83 | USP30 (0.50) | — | |
| SCHEMBL8419333 | 0.82 | GAA (0.57) | SMN1; SMN2KDM4ENPY2RNPC1RAB9A | |
| SCHEMBL24590454 | 0.81 | NAMPT (0.47) | MAPTKMT2AMEN1ALDH1A1SCD | |
| SCHEMBL24590680 | 0.81 | TEAD3 (0.47) | HRH1KMT2ARBP4SCD | |
| SCHEMBL28278842 | 0.81 | EPHX2 (0.57) | HRH1SMN1; SMN2KDM4ENPY1RNPY2R | |
| SCHEMBL5114227 | 0.81 | HPGD (0.47) | SMN1; SMN2KDM4ENPY1RNPY2RKMT2A | |
| SCHEMBL28086838 | 0.80 | PTGDR2 (0.37) | PTGDR2SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL24590535 | 0.80 | NAMPT (0.49) | SMN1; SMN2KMT2AMEN1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315763-A1 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-05-04 | — | — | EP | disclosed |
| WO-2010003048-A1 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |