Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | STAT6 | P42226 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18990106 | 0.91 | MAPT (0.74) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL20592316 | 0.79 | MAPT (0.69) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18989932 | 0.78 | MAPT (0.74) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL19012416 | 0.78 | MTHFD2 (0.93) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18990229 | 0.78 | HIF1A (0.69) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18990152 | 0.78 | MAPT (0.80) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18989991 | 0.77 | MAPT (0.82) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL20592265 | 0.77 | MAPT (0.72) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18989768 | 0.77 | MAPT (0.67) | MAPTTP53MTHFD2USP2TSHR | |
| SCHEMBL18990557 | 0.77 | MAPT (0.67) | MAPTTP53MTHFD2USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |