Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | FURIN | P09958 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.41 |
| ▸ | MASP2 | O00187 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902369 | 0.92 | PDPK1 (0.42) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL1903648 | 0.92 | PDPK1 (0.42) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL1432320 | 0.90 | PDPK1 (0.42) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL3148328 | 0.90 | PDPK1 (0.47) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL1901309 | 0.89 | NAMPT (0.46) | FURINKLKB1MASP2NAMPTGRIA1 | |
| SCHEMBL1432268 | 0.87 | CTSS (0.50) | PDPK1FURINKLKB1 | |
| SCHEMBL1431798 | 0.85 | PDPK1 (0.42) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL1431792 | 0.85 | PDPK1 (0.42) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL3153543 | 0.85 | FURIN (0.43) | PDPK1FURINKLKB1MASP2NAMPT | |
| SCHEMBL3153517 | 0.85 | FURIN (0.43) | PDPK1FURINKLKB1MASP2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |