Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18989914 | 0.93 | MTHFD2 (0.65) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990235 | 0.91 | MTHFD2 (0.68) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18991164 | 0.89 | MTHFD2 (0.64) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990710 | 0.88 | MTHFD2 (0.63) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990788 | 0.88 | MTHFD2 (0.65) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL19014110 | 0.88 | MTHFD2 (0.59) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990148 | 0.87 | MTHFD2 (0.65) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990126 | 0.86 | MTHFD2 (0.63) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL18990567 | 0.86 | MTHFD2 (0.68) | MTHFD2TP53POLBMEN1KMT2A | |
| SCHEMBL31423701 | 0.86 | MTHFD2 (0.62) | MTHFD2TP53POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106352-A1 | CAFFEINE INHIBITORS OF MTHFD2 AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-06-22 | — | — | WO | disclosed |