Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874765 | 0.78 | HTT (0.58) | POLBLMNASMN1; SMN2KMT2AHTT | |
| SCHEMBL18704630 | 0.77 | CYP1A2 (0.44) | SMN1; SMN2 | |
| SCHEMBL12311362 | 0.77 | POLB (0.65) | POLBLMNASMN1; SMN2KMT2AHTT | |
| SCHEMBL1008489 | 0.77 | ALDH1A1 (0.35) | LMNAKMT2AALDH1A1 | |
| SCHEMBL12895864 | 0.77 | POLB (0.65) | POLBLMNAKMT2AHTTMAPK1 | |
| SCHEMBL14595370 | 0.76 | — | — | |
| SCHEMBL14536911 | 0.75 | POLB (0.62) | POLBLMNASMN1; SMN2KMT2AHTT | |
| SCHEMBL13752301 | 0.75 | POLB (0.62) | POLBLMNASMN1; SMN2KMT2AHTT | |
| SCHEMBL14018620 | 0.75 | POLB (0.62) | POLBLMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL13208402 | 0.75 | POLB (0.62) | POLBLMNASMN1; SMN2KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103188-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-22 | — | — | WO | disclosed |