Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298254 | 0.82 | TSHR (0.68) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL10010571 | 0.80 | TSHR (0.67) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL1373745 | 0.80 | TSHR (0.67) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL10010574 | 0.80 | TSHR (0.67) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL4675666 | 0.80 | TSHR (0.67) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL26670065 | 0.78 | TSHR (0.64) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL11509921 | 0.77 | TSHR (0.62) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL16048460 | 0.77 | TSHR (0.62) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL27380746 | 0.77 | TSHR (0.62) | TSHRALDH1A1TDP1SMN1; SMN2HPGD | |
| SCHEMBL24562 | 0.76 | TSHR (1.00) | TSHRALDH1A1TDP1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017106069-A1 | ANTIVIRAL OXIME PHOSPHORAMIDE COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |