Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19774219 | 0.89 | MET (0.39) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL15742257 | 0.87 | KDM4C (0.38) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL26975094 | 0.87 | KDM4C (0.38) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL19774074 | 0.81 | MEN1 (0.39) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL26647214 | 0.80 | NPC1 (0.40) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL15742159 | 0.80 | MET (0.34) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL20228835 | 0.79 | KDM4C (0.42) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL8297005 | 0.79 | MET (0.44) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL16279570 | 0.79 | MET (0.39) | NPC1RAB9AKDM4CMETMEN1 | |
| SCHEMBL15508809 | 0.76 | MET (0.44) | NPC1RAB9AKDM4CMETMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181564-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | HOFFMANN LA ROCHE (CH) | 2019-09-18 | — | — | EP | disclosed |
| EP-2922851-B1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | GENENTECH INC (US) | 2017-07-26 | — | — | EP | disclosed |
| EP-3181564-A1 | AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS | Genentech, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |