Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19016323 | 0.86 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL20136946 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL1668653 | 0.83 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL29323231 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNAL3MBTL1MAPTHTT | |
| SCHEMBL26985988 | 0.82 | PPARA (0.52) | L3MBTL1SYKCTSSPPARASLC1A1 | |
| SCHEMBL24572425 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL4513964 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL20526175 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL18886286 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAL3MBTL1SYKMAPT | |
| SCHEMBL29323035 | 0.82 | SMN1; SMN2 (0.68) | SMN1; SMN2LMNAL3MBTL1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103824-A1 | TRICYCLIC COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2017-06-22 | — | — | WO | disclosed |