Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.35 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902104 | 0.91 | TNK2 (0.35) | PDE2ATACR3TNK2KLKB1KLK1 | |
| SCHEMBL14119075 | 0.91 | AKT1 (0.40) | PDE2ATNK2SLC6A9LCK | |
| SCHEMBL1902285 | 0.91 | ALDH1A1 (0.41) | ALDH1A1HPGD | |
| SCHEMBL14118606 | 0.90 | PDE2A (0.38) | PDE2ATNK2CHEK1SLC6A9AURKA | |
| SCHEMBL1902450 | 0.88 | ALDH1A1 (0.35) | PDE2ATACR3TNK2CHEK1AURKA | |
| SCHEMBL1903809 | 0.88 | ALDH1A1 (0.38) | PDE2ATACR3TNK2ALDH1A1LCK | |
| SCHEMBL1905588 | 0.88 | KDM4E (0.34) | PDE2ATACR3TNK2KLKB1KLK1 | |
| SCHEMBL1903936 | 0.87 | PDE2A (0.33) | PDE2ATACR3TNK2KLKB1KLK1 | |
| SCHEMBL1905986 | 0.85 | AURKA (0.39) | PDE2ATACR3TNK2CHEK1AURKA | |
| SCHEMBL14119069 | 0.83 | AKT1 (0.41) | PDE2ATNK2ALDH1A1LCKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | disclosed |
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309739-A1 | AKT / PKB INHIBITORS | AKT1, AKT2, AKT3 | PDE2A 2363/4885TACR3 3761/4885TNK2 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.