Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | GPX4 | P36969 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20261599 | 0.98 | ALDH1A1 (0.44) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL19017604 | 0.91 | ALDH1A1 (0.43) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL32689936 | 0.90 | ALDH1A1 (0.42) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL20082945 | 0.90 | NPC1 (0.43) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL19017644 | 0.90 | ALDH1A1 (0.43) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL19427238 | 0.89 | NPC1 (0.42) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL20082951 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL17065306 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL19243861 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL24243190 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181567-B1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC (US) | 2019-03-20 | — | — | EP | disclosed |
| EP-3181567-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS | PRINCIPIA BIOPHARMA, INC. (US) | 2017-06-21 | — | — | EP | disclosed |