Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.69 |
| ▸ | GRM5 | P41594 | 3/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1643058 | 0.86 | FFAR1 (0.64) | FFAR1GRM5ACACBAPPFFAR4 | |
| SCHEMBL19116244 | 0.79 | FFAR1 (0.59) | FFAR1GRM5ACACBAPPMAPT | |
| SCHEMBL30998264 | 0.78 | FFAR1 (0.44) | FFAR1ACACB | |
| SCHEMBL30998248 | 0.77 | FFAR1 (0.41) | FFAR1ACACBEGLN1 | |
| SCHEMBL8569361 | 0.77 | FFAR1 (0.41) | FFAR1ACACB | |
| SCHEMBL6041956 | 0.73 | NPC1 (0.47) | FFAR1 | |
| SCHEMBL1644125 | 0.72 | GRM5 (0.57) | FFAR1GRM5APPEGLN1MAPT | |
| SCHEMBL10848914 | 0.70 | FFAR1 (0.50) | FFAR1GRM5ACACBEGLN1 | |
| SCHEMBL14840557 | 0.69 | FFAR1 (0.56) | FFAR1GRM5EGLN1PLAUPLAT | |
| SCHEMBL1663193 | 0.69 | GRM5 (0.45) | FFAR1GRM5APPFFAR4EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493856-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | F. Hoffmann-La Roche AG (CH) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051201-A1 | POSITIVE ALLOSTERIC MODULATORS (PAM) | F. HOFFMANN-LA ROCHE AG (CH) | 2011-05-05 | — | — | WO | disclosed |