Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18973377 | 1.00 | PDE3B (0.40) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL20976650 | 0.93 | RPS6KA3 (0.39) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL2741547 | 0.91 | PDE3B (0.42) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL2741562 | 0.91 | PDE3B (0.42) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL13295485 | 0.89 | PDE3B (0.41) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL17471815 | 0.88 | PTGS2 (0.36) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL13480360 | 0.87 | PDE3B (0.40) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL18973378 | 0.86 | PDE3B (0.40) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL170435 | 0.85 | PDE3B (0.49) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 | |
| SCHEMBL21373998 | 0.84 | PTGS2 (0.45) | PDE3BPDE3ARPS6KA3PDK2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102053-A2 | CINNAMIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |