Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 20/20 | 0.86 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.86 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.86 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.86 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.86 |
| ▸ | NCOR2 | Q9Y618 | 9/20 | 0.86 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.86 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.86 |
| ▸ | UBA1 | P22314 | 1/20 | 0.73 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.73 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.73 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17305526 | 1.00 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL22810153 | 1.00 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL21586611 | 1.00 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL19047320 | 1.00 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL12611184 | 0.93 | HDAC3 (0.88) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL12651856 | 0.93 | HDAC3 (0.88) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL10315069 | 0.93 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| Largazole Thiol SCHEMBL15195503 | 0.93 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| SCHEMBL12610998 | 0.93 | HDAC3 (0.86) | HDAC3HDAC1HDAC2HDAC6HDAC8 | |
| Largazole Thiol SCHEMBL7994520 | 0.93 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12252511-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2025-03-18 | — | — | US | disclosed |
| US-11739123-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739123-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-11739123-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20220002347-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-20220002347-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE, INC. (US) | 2022-01-06 | — | — | US | disclosed |
| US-11053284-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053284-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| EP-3578179-B1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | ONKURE INC (US) | 2020-12-23 | — | — | EP | disclosed |
| US-20200347097-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-20200347097-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2020-11-05 | — | — | US | disclosed |
| US-10689419-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-10689419-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| EP-3578179-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | Onkure, Inc. (US) | 2019-12-11 | — | — | EP | disclosed |
| US-20190177372-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2019-06-13 | — | — | US | disclosed |
| US-10100089-B2 | Process for the preparation of cyclic depsipeptides | ONKURE, INC. (US) | 2018-10-16 | — | — | US | disclosed |
| US-20170183382-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2017-06-29 | — | — | US | disclosed |
| US-20170183382-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2017-06-29 | — | — | US | disclosed |
| US-20170183382-A1 | Process for the Preparation of Cyclic Depsipeptides | ONKURE, INC. (US) | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177372-A1 | Process for the Preparation of Cyclic Depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-11739123-B2 | Process for the preparation of cyclic depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-11053284-B2 | Process for the preparation of cyclic depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-20220002347-A1 | PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-20170183382-A1 | Process for the Preparation of Cyclic Depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-10100089-B2 | Process for the preparation of cyclic depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-10689419-B2 | Process for the preparation of cyclic depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-12252511-B2 | Process for the preparation of cyclic depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
| US-20200347097-A1 | Process for the Preparation of Cyclic Depsipeptides | VIP, LPXN, NGLY1 | HDAC3 2315/4885HDAC1 1152/4885HDAC2 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.