Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | CCKAR | P32238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900405 | 1.00 | DRD2 (0.40) | DRD2HTR1AHTR2APTGDR2TBXA2R | |
| SCHEMBL1902305 | 1.00 | DRD2 (0.40) | DRD2HTR1AHTR2APTGDR2TBXA2R | |
| SCHEMBL1898546 | 0.90 | CA1 (0.39) | PTGDR2TBXA2RPTGDRPOLBMEN1 | |
| SCHEMBL1904450 | 0.90 | CA1 (0.39) | PTGDR2TBXA2RPTGDRPOLBMEN1 | |
| SCHEMBL1898544 | 0.90 | CA1 (0.39) | PTGDR2TBXA2RPTGDRPOLBMEN1 | |
| SCHEMBL1905551 | 0.89 | CA1 (0.48) | MEN1TSHRKMT2ACA1CA2 | |
| SCHEMBL1903304 | 0.89 | CA1 (0.48) | MEN1TSHRKMT2ACA1CA2 | |
| SCHEMBL831617 | 0.89 | CA1 (0.48) | MEN1TSHRKMT2ACA1CA2 | |
| SCHEMBL1900255 | 0.87 | KMT2A (0.42) | DRD2PTGDR2TBXA2RPTGDRPOLB | |
| SCHEMBL2489546 | 0.87 | KMT2A (0.42) | DRD2PTGDR2TBXA2RPTGDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |