Known targets — ChEMBL curated mechanism
DRD2DRD3HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7
The experimentally established mechanism targets of Amisulpride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 9/20 | 0.86 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.86 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.86 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.86 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.86 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.86 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.86 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.86 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | HRH1 | P35367 | 1/20 | 0.86 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.83 |
| ▸ | CA2 | P00918 | 2/20 | 0.73 |
| ▸ | DRD1 | P21728 | 2/20 | 0.73 |
| ▸ | DRD4 | P21917 | 2/20 | 0.73 |
| ▸ | CA9 | Q16790 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amisulpride SCHEMBL3650031 | 0.97 | DRD2 (0.81) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL34126 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL29506665 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL20206474 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL29508640 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL6403721 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL675545 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL29508664 | 0.93 | DRD2 (1.00) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL21046204 | 0.92 | DRD2 (0.98) | DRD2DRD3ADRA2BADRA2CHTR2B | |
| Amisulpride SCHEMBL21046205 | 0.92 | DRD2 (0.98) | DRD2DRD3ADRA2BADRA2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323627-A1 | NOVEL RAPID-EFFECT PHARMACEUTICAL FORMS AND USES OF RESULTING PHARMACEUTICAL COMPOSITIONS | Bionetwork (FR) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010007232-A9 | NOVEL RAPID-EFFECT PHARMACEUTICAL FORMS AND USES OF RESULTING PHARMACEUTICAL COMPOSITIONS | BIONETWORK (FR) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010007232-A1 | NOVEL RAPID-EFFECT PHARMACEUTICAL FORMS AND USES OF RESULTING PHARMACEUTICAL COMPOSITIONS | BIONETWORK (FR) | 2010-01-21 | — | — | WO | disclosed |