Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MASP2 | O00187 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.35 |
| ▸ | CPB1 | P15086 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1431917 | 0.89 | PSMB10 (0.40) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1431923 | 0.89 | PSMB10 (0.40) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1903263 | 0.88 | MASP2 (0.40) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1432229 | 0.88 | MASP2 (0.43) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1908006 | 0.88 | MASP2 (0.41) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1903269 | 0.88 | MASP2 (0.40) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1432232 | 0.88 | MASP2 (0.43) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL3148239 | 0.88 | MASP2 (0.43) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1907930 | 0.88 | MASP2 (0.41) | MASP2PSMB10PSMB2CPB2CPB1 | |
| SCHEMBL1431974 | 0.88 | MASP2 (0.44) | MASP2PSMB10PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |