SCHEMBL1903178

SCHEMBL1903178

OC(CNC(c1cccc(Oc2ccc(F)cc2)c1)c1cccc(C(F)(F)C(F)(F)C(F)(F)F)c1)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CETP P11597 15/20 0.39
SLC6A9 P48067 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6277527 1.00 CETP (0.39) CETPSLC6A9
SCHEMBL5669352 0.94 CETP (0.40) CETPSLC6A9
SCHEMBL5669140 0.94 CETP (0.40) CETPSLC6A9
SCHEMBL6386490 0.93 CETP (0.42) CETP
SCHEMBL995355 0.93 CETP (0.42) CETP
SCHEMBL5671544 0.91 CETP (0.43) CETP
SCHEMBL13837709 0.91 CETP (0.39) CETP
SCHEMBL1900758 0.91 CETP (0.39) CETP
SCHEMBL6064717 0.89 CETP (0.42) CETP
SCHEMBL6231524 0.89 CETP (0.42) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2316447-A1 Method of inhibiting remnant lipoprotein production Japan Tobacco, Inc. (JP) 2011-05-04 EP disclosed
EP-1469831-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID AMORPHOUS DISPERSION OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS Pfizer Products Inc. (US) 2004-10-27 EP disclosed
EP-1401399-A2 PHARMACEUTICAL COMPOSITIONS CONTAINING POLYMER AND DRUG ASSEMBLIES Pfizer Products Inc. (US) 2004-03-31 EP disclosed
WO-2003063832-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID AMORPHOUS DISPERSION OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS PFIZER PRODUCTS INC. (US) 2003-08-07 WO disclosed
WO-2003000226-A2 PHARMACEUTICAL COMPOSITIONS CONTAINING POLYMER AND DRUG ASSEMBLIES PFIZER PRODUCTS INC. (US) 2003-01-03 WO disclosed