Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904172 | 0.90 | AKT1 (0.55) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL15276684 | 0.89 | AURKA (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL16444043 | 0.89 | AURKA (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL15276626 | 0.89 | AURKA (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| Hydrochloric Acid SCHEMBL15265226 | 0.89 | AURKA (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL15276625 | 0.89 | ALDH1A1 (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL15276600 | 0.89 | ALDH1A1 (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL16444190 | 0.89 | ALDH1A1 (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| Hydrochloric Acid SCHEMBL15265223 | 0.89 | AURKA (0.39) | AKT1ALDH1A1KDM4ENPSR1HPGD | |
| SCHEMBL1899701 | 0.88 | AKT1 (0.44) | AKT1ALDH1A1KDM4ENPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | claimed |
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | claimed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | claimed |
| EP-2838901-B1 | 6-(4-(1-AMINO-3-HYDROXYCYCLOBUTYL)PHENYL)-5-PHENYL(FURO, THIENO OR PYRROLO)[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES FOR THE TREATMENT OF CANCER | ALMAC DISCOVERY LTD (GB) | 2016-11-02 | — | — | EP | disclosed |
| US-9156853-B2 | AKT inhibitor compounds for treatment of cancer | ALMAC DISCOVERY LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-9156853-B2 | AKT inhibitor compounds for treatment of cancer | ALMAC DISCOVERY LIMITED (GB) | 2015-10-13 | — | — | US | disclosed |
| US-20150045377-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | US | disclosed |
| US-20150045377-A1 | PHARMACEUTICAL COMPOUNDS | ALMAC DISCOVERY LIMITED (GB) | 2015-02-12 | — | — | US | disclosed |
| WO-2013140189-A1 | 6- (4- (1 -AMINO- 3 -HYDROXYCYCLOBUTYL) PHENYL) - 5 - PHENYL (FURO, THIENO OR PYRROLO) [2, 3-D] PYRIMIDIN- 4 - ONE DERIVATIVES FOR THE TREATMENT OF CANCER | ALMAC DISCOVERY LIMITED (GB) | 2013-09-26 | — | — | WO | disclosed |
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | disclosed |
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | disclosed |
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | disclosed |
| EP-2496566-A1 | AKT / PKB INHIBITORS | Almac Discovery Limited (GB) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011055115-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045377-A1 | PHARMACEUTICAL COMPOUNDS | PLK1, PIK3CA, AKT2 | AKT1 5/4885ALDH1A1 3278/4885KDM4E 2080/4885 |
| US-20120309739-A1 | AKT / PKB INHIBITORS | AKT1, AKT2, AKT3 | AKT1 1/4885ALDH1A1 4803/4885KDM4E 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.