Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19032881 | 0.92 | CFTR (1.00) | CFTR | |
| SCHEMBL19032793 | 0.89 | CFTR (1.00) | CFTR | |
| SCHEMBL19032883 | 0.89 | CFTR (1.00) | CFTR | |
| SCHEMBL19032882 | 0.89 | CFTR (0.80) | CFTR | |
| SCHEMBL19032873 | 0.87 | CFTR (0.79) | CFTR | |
| SCHEMBL19032762 | 0.86 | CFTR (0.77) | CFTR | |
| SCHEMBL19032835 | 0.84 | CFTR (0.81) | CFTRTDP1 | |
| SCHEMBL19032732 | 0.83 | CFTR (0.85) | CFTR | |
| SCHEMBL19032867 | 0.82 | CFTR (1.00) | CFTR | |
| SCHEMBL19032884 | 0.80 | CFTR (0.74) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503447-B2 | CFTR regulators and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-12-23 | — | — | US | disclosed |
| EP-4071140-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2022-10-12 | — | — | EP | disclosed |
| US-20210347742-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-11-11 | — | — | US | disclosed |
| US-11084795-B2 | CFTR regulators and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-10 | — | — | US | disclosed |
| CN-108699040-B | Modulators of CFTR and methods of use thereof | 加利福尼亚大学董事会 | 2021-08-10 | — | — | CN | disclosed |
| US-20190031622-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-31 | — | — | US | disclosed |
| EP-3394046-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of the University of California, A California Corporation (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017112950-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031622-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | CFTR, SLC26A4, CLCN2 | CFTR 1/4885TDP1 2925/4885 |
| US-20210347742-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | CFTR, SLC26A4, CLCN2 | CFTR 1/4885TDP1 2925/4885 |
| US-11084795-B2 | CFTR regulators and methods of use thereof | CFTR, SLC26A4, CLCN2 | CFTR 1/4885TDP1 2925/4885 |
| US-12503447-B2 | CFTR regulators and methods of use thereof | CFTR, SLC26A4, CLCN2 | CFTR 1/4885TDP1 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.