Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21580364 | 1.00 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL22504456 | 0.81 | TDP1 (0.44) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL2454828 | 0.79 | HTR2A (0.45) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL2531926 | 0.75 | HTR2A (0.49) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL21580360 | 0.73 | MAPK1 (0.30) | — | |
| SCHEMBL9247606 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL16090421 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL9611933 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MAPTHPGDTDP1ATM | |
| SCHEMBL15478418 | 0.72 | HTR2A (0.46) | ALDH1A1MAPTHPGDTDP1POLB | |
| SCHEMBL11932224 | 0.71 | HTR2A (0.45) | ALDH1A1MAPTHPGDTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688711-B2 | Antibacterial aminoglycoside analogs | ACHAOGEN, INC. (US) | 2017-06-27 | — | — | US | disclosed |