Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19036593 | 0.78 | KDM1A (0.44) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL15075966 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL19036537 | 0.73 | KDM1A (0.40) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL15075715 | 0.72 | EPHX2 (0.35) | — | |
| SCHEMBL19036641 | 0.61 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTNPSR1 | |
| SCHEMBL20725308 | 0.55 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL133905 | 0.54 | HPGD (0.40) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL515834 | 0.54 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL10309075 | 0.54 | GAA (0.57) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL1546631 | 0.53 | EPHX2 (0.52) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184527-A1 | 2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL | Hydra Biosciences, Inc. (US) | 2017-06-28 | — | — | EP | disclosed |