Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 17/20 | 0.73 |
| ▸ | CCNH | P51946 | 17/20 | 0.73 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.62 |
| ▸ | CDK1 | P06493 | 2/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | CDK9 | P50750 | 2/20 | 0.62 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.62 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.62 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.62 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.62 |
| ▸ | CCNK | O75909 | 1/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.62 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.62 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024448 | 0.90 | CDK7 (0.70) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL17150571 | 0.90 | CDK7 (0.70) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL18313520 | 0.84 | CDK7 (1.00) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL17150572 | 0.84 | CDK7 (0.87) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL19024466 | 0.84 | CDK7 (0.87) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL19054705 | 0.83 | CDK7 (0.64) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL19040086 | 0.82 | CDK7 (0.51) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL17141331 | 0.81 | CDK7 (0.61) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL15648063 | 0.79 | CDK5 (0.72) | CDK7CCNHCDK5CDK1CDK2 | |
| SCHEMBL15648061 | 0.79 | CDK5 (0.72) | CDK7CCNHCDK5CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180208578-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2018-07-26 | — | — | US | disclosed |
| US-20170183355-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2017-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208578-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | CDK7 1/4885CCNH 31/4885CDK5 11/4885 |
| US-20170183355-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | CDK7, CDK3, CDK9 | CDK7 1/4885CCNH 31/4885CDK5 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.