Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904070 | 1.00 | PTGDR2 (0.39) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1904355 | 0.93 | NPC1 (0.43) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL2494030 | 0.93 | NPC1 (0.43) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1905495 | 0.93 | PTGDR2 (0.43) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1905496 | 0.93 | PTGDR2 (0.43) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1903518 | 0.93 | PTGDR2 (0.39) | PTGDR2NPC1MTNR1AMTNR1B | |
| SCHEMBL1903517 | 0.93 | PTGDR2 (0.39) | PTGDR2NPC1MTNR1AMTNR1B | |
| SCHEMBL2490412 | 0.91 | SIGMAR1 (0.39) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1904906 | 0.91 | SIGMAR1 (0.39) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B | |
| SCHEMBL1902936 | 0.87 | PTGDR2 (0.41) | PTGDR2SIGMAR1NPC1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |