Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.84 |
| ▸ | PGR | P06401 | 15/20 | 0.84 |
| ▸ | AR | P10275 | 11/20 | 0.84 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | SHBG | P04278 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19042730 | 1.00 | NR3C1 (0.84) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL19042731 | 0.91 | NR3C1 (1.00) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL22861557 | 0.91 | NR3C1 (1.00) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL19042672 | 0.90 | NR3C1 (1.00) | NR3C1PGRARCYP2C8THRB | |
| SCHEMBL22861542 | 0.90 | NR3C1 (1.00) | NR3C1PGRARCYP2C8THRB | |
| SCHEMBL20048343 | 0.88 | NR3C1 (0.76) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL20048067 | 0.88 | NR3C1 (0.85) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL20048338 | 0.87 | NR3C1 (0.85) | NR3C1PGRARCYP2C8 | |
| SCHEMBL20048346 | 0.83 | NR3C1 (0.85) | NR3C1PGRARCYP2C8HIF1A | |
| SCHEMBL30324821 | 0.83 | NR3C1 (0.85) | NR3C1PGRARCYP2C8HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017112909-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2017-06-29 | — | — | WO | disclosed |