Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1435751 | 0.77 | MEN1 (0.68) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL1435755 | 0.77 | MEN1 (0.68) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL27320824 | 0.77 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL707776 | 0.76 | TDP1 (0.51) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL707775 | 0.76 | TDP1 (0.51) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL721182 | 0.74 | MEN1 (0.79) | NPC1RAB9AMEN1KMT2AATM | |
| Methyl Alcohol SCHEMBL28478479 | 0.74 | NPC1 (0.89) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL721181 | 0.74 | MEN1 (0.79) | NPC1RAB9AMEN1KMT2AATM | |
| SCHEMBL5599268 | 0.74 | ALDH1A1 (0.59) | TDP1ALDH1A1TSHRKDM4EMAPT | |
| SCHEMBL5599265 | 0.74 | ALDH1A1 (0.59) | TDP1ALDH1A1TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |