Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21439343 | 0.98 | HRH3 (0.53) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL21439516 | 0.98 | HRH3 (0.53) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL11479249 | 0.86 | GRIN2D (0.46) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL21439166 | 0.84 | HRH3 (0.57) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL20382733 | 0.84 | HRH3 (0.46) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL358258 | 0.84 | GRIN2D (0.57) | SIGMAR1GRIN2DGRIN3BADRA1AGRIN1 | |
| SCHEMBL359213 | 0.84 | GRIN2D (0.57) | SIGMAR1GRIN2DGRIN3BADRA1AGRIN1 | |
| SCHEMBL11434667 | 0.83 | KMT2A (0.51) | HRH3SIGMAR1CHRM2ADRA2BDRD3 | |
| SCHEMBL11159052 | 0.82 | GRIN2D (0.56) | HRH3SIGMAR1GRIN2DGRIN3BADRA1A | |
| SCHEMBL9370705 | 0.81 | SIGMAR1 (0.63) | HRH3SIGMAR1DRD3ALDH1A1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |