Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MASP2 | O00187 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | FURIN | P09958 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1904480 | 1.00 | NAMPT (0.45) | NAMPTPOLBRAB9AKLKB1ALDH1A1 | |
| SCHEMBL1901348 | 0.91 | KLKB1 (0.42) | NAMPTKLKB1MASP2KLK1KMT2A | |
| SCHEMBL1901351 | 0.91 | KLKB1 (0.42) | NAMPTKLKB1MASP2KLK1KMT2A | |
| SCHEMBL1903197 | 0.91 | ALDH1A1 (0.49) | NAMPTKLKB1ALDH1A1MASP2KLK1 | |
| SCHEMBL1906052 | 0.91 | KLKB1 (0.47) | KLKB1MASP2KLK1 | |
| SCHEMBL1902345 | 0.91 | KLKB1 (0.47) | KLKB1MASP2KLK1 | |
| SCHEMBL1903189 | 0.91 | ALDH1A1 (0.49) | NAMPTKLKB1ALDH1A1MASP2KLK1 | |
| SCHEMBL1904105 | 0.91 | NAMPT (0.44) | NAMPTKLKB1ALDH1A1MASP2KLK1 | |
| SCHEMBL1904109 | 0.91 | NAMPT (0.44) | NAMPTKLKB1ALDH1A1MASP2KLK1 | |
| SCHEMBL1905072 | 0.90 | NAMPT (0.46) | NAMPTKLKB1ALDH1A1MASP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051671-A1 | AMINOPYRIDINE DERIVATIVES AS KALLIKREIN INHIBITORS | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |