Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19045689 | 0.76 | IRAK4 (0.56) | IRAK4 | |
| SCHEMBL28240880 | 0.75 | IRAK4 (0.31) | IRAK4 | |
| SCHEMBL19030794 | 0.73 | CYP1A2 (0.38) | — | |
| SCHEMBL19030561 | 0.72 | PDK2 (0.38) | — | |
| SCHEMBL19030062 | 0.63 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL19045681 | 0.61 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL19045306 | 0.58 | HDAC3 (0.40) | IRAK4 | |
| SCHEMBL30714925 | 0.57 | SLC5A1 (0.40) | IRAK4 | |
| SCHEMBL28210543 | 0.57 | HPGD (0.41) | — | |
| SCHEMBL19030537 | 0.56 | AKR1B1 (0.35) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |