Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23277898 | 0.81 | AKR1B1 (0.34) | IRAK4 | |
| SCHEMBL19030794 | 0.76 | CYP1A2 (0.38) | — | |
| SCHEMBL19045077 | 0.75 | IRAK4 (0.36) | IRAK4 | |
| SCHEMBL19046264 | 0.74 | — | — | |
| SCHEMBL19030561 | 0.72 | PDK2 (0.38) | — | |
| SCHEMBL19030062 | 0.63 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL28241753 | 0.63 | ALDH1A1 (0.46) | — | |
| SCHEMBL19046313 | 0.60 | ALDH1A1 (0.31) | IRAK4 | |
| SCHEMBL31410947 | 0.60 | TDP1 (0.34) | IRAK4 | |
| SCHEMBL15800554 | 0.59 | GRIN2D (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-A | Pyrazolo [1,5a] pyrimidine derivatives as IRAK4 conditioning agents | 豪夫迈·罗氏有限公司 | 2018-08-31 | — | — | CN | disclosed |