Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19029978 | 0.84 | GPR119 (0.44) | USP2SMN1; SMN2GPR119IRAK4HRH3 | |
| SCHEMBL29935368 | 0.84 | GPR119 (0.44) | USP2SMN1; SMN2GPR119IRAK4HRH3 | |
| SCHEMBL19030303 | 0.83 | MAPT (0.46) | USP2SMN1; SMN2GPR119IRAK4HRH3 | |
| SCHEMBL19045086 | 0.81 | IRAK4 (0.46) | USP2SMN1; SMN2IRAK4 | |
| SCHEMBL25343723 | 0.75 | GPR119 (0.49) | USP2SMN1; SMN2GPR119HRH3 | |
| SCHEMBL19045690 | 0.74 | IRAK4 (0.46) | IRAK4 | |
| SCHEMBL19030530 | 0.73 | GPR119 (0.43) | SMN1; SMN2GPR119HRH3 | |
| SCHEMBL31024670 | 0.72 | GPR119 (0.46) | GPR119HRH3 | |
| SCHEMBL20270723 | 0.71 | GPR119 (0.53) | GPR119HRH3 | |
| SCHEMBL25335823 | 0.71 | GPR119 (0.48) | GPR119HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |