Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19045086 | 0.85 | IRAK4 (0.46) | — | |
| SCHEMBL31024670 | 0.81 | GPR119 (0.46) | GPR119HRH3IDO1KMT2A | |
| SCHEMBL19030363 | 0.80 | GPR119 (0.48) | GPR119HRH3HDAC2HDAC1KMT2A | |
| SCHEMBL19030530 | 0.80 | GPR119 (0.43) | GPR119HRH3KMT2A | |
| SCHEMBL25343723 | 0.79 | GPR119 (0.49) | GPR119HRH3IDO1KMT2A | |
| SCHEMBL19045959 | 0.78 | IRAK4 (0.36) | — | |
| SCHEMBL15178387 | 0.76 | KMT2A (0.55) | GPR119HDAC2HDAC1KMT2A | |
| SCHEMBL13919430 | 0.75 | GPR119 (0.53) | GPR119HRH3HDAC2HDAC1IDO1 | |
| SCHEMBL20270723 | 0.75 | GPR119 (0.53) | GPR119HRH3HDAC2HDAC1IDO1 | |
| SCHEMBL31235967 | 0.75 | GPR119 (0.56) | GPR119HRH3HDAC2HDAC1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |