Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 13/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046207 | 0.86 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL19030693 | 0.77 | IRAK4 (0.48) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19030317 | 0.76 | MAPT (0.44) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19046393 | 0.74 | IRAK4 (0.74) | IRAK4 | |
| SCHEMBL19030031 | 0.74 | IRAK4 (0.43) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19030950 | 0.69 | IRAK4 (0.51) | IRAK4 | |
| SCHEMBL19030023 | 0.69 | ESPL1 (0.39) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19030707 | 0.67 | IRAK4 (0.48) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19030135 | 0.66 | MAPT (0.47) | IRAK4MAPTLMNAALDH1A1 | |
| SCHEMBL19030476 | 0.66 | IRAK4 (0.49) | IRAK4MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017108723-A2 | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2017-06-29 | — | — | WO | disclosed |