ESPL1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16655365	0.63	8/20
SCHEMBL10082444	0.47	6/20
Iodide (SCHEMBL6537514)	0.46	6/20
SCHEMBL18061381	0.71	4/20
SCHEMBL31557573	0.57	4/20
SCHEMBL1011205	0.41	4/20
SCHEMBL9904957	0.40	4/20
SCHEMBL8000338	0.50	3/20
SCHEMBL8000251	0.49	3/20
SCHEMBL397584	0.43	3/20
SCHEMBL11323346	0.42	3/20
SCHEMBL4872661	0.42	3/20
SCHEMBL397120	0.41	3/20
SCHEMBL21750749	0.39	3/20
SCHEMBL26688824	0.38	3/20
SCHEMBL22228333	0.52	2/20
SCHEMBL7996831	0.49	2/20
SCHEMBL9486251	0.45	2/20
SCHEMBL9590694	0.44	2/20
SCHEMBL31284553	0.44	2/20

Clinical trials — most relevant to ESPL1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Efficacy and Safety Assessment of Oral LBH589 in Adult Patients With Advanced Soft TIssue Sarcoma After Pre-treatment Failure	PHASE2	COMPLETED
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer	PHASE2	COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety	PHASE2	COMPLETED
ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk Myelodysplastic Syndrome	PHASE1/PHASE2	RECRUITING
Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer	PHASE2	COMPLETED
NY-ESO-1 Protein With Montanide and CpG 7909 as Cancer Vaccine in Several Tumors	PHASE1	COMPLETED
Dose Escalation Study of Immunomodulatory Nanoparticles	PHASE1	ACTIVE_NOT_RECRUITING
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations	EARLY_PHASE1	COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus	EARLY_PHASE1	COMPLETED
Mesenchymal Stem Cells in NPM1 Mutated Low Risk Acute Myeloid Leukemia: a Study of the Tumor Microenvironment and Its Contribution to the Outcome	nan	COMPLETED
Investigation Into Detection of Prostate Cancer Using Voided Urine (Prostate VPAC)	nan	RECRUITING
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2	nan	UNKNOWN
Genetic Investigation of Solid Tumors Cohort	nan	COMPLETED
Study of Tazemetostat in Adults With Follicular Lymphoma Previously Treated With at Least Two Therapies	nan	WITHDRAWN
Identification of Biomarkers for Early Detection of Pancreatic Cancer	nan	COMPLETED
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders	nan	COMPLETED
SLPI for Prostate Cancer	nan	UNKNOWN
Familial Prostate Cancer	nan	COMPLETED
Genetics of Prostate Cancer in Young Patients	nan	COMPLETED
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma	nan	COMPLETED
A Registry for Hereditary Cancer Risk Assessment and Genetic Testing	nan	COMPLETED
Investigation of Copy Number Variations and Genetic Variants in POI	nan	RECRUITING
Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma	nan	RECRUITING
Characterization of Microbiological and Genetic Features in Prostate Cancer and Their Association with Disease Stage	nan	ENROLLING_BY_INVITATION
Immunophenotyping and Xist Gene in AML	nan	UNKNOWN
Biomarkers of Lichen Sclerosus	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ESPL1 binder may also engage these)

Protein	Name	Similarity
P60330	—	0.998	P60330 →
Q9EQR6	—	0.992	Q9EQR6 →
O43299	—	0.988	O43299 →
E9PVA8	—	0.987	E9PVA8 →
E7FGT5	—	0.987	E7FGT5 →
Q5PNP6	—	0.987	Q5PNP6 →
Q5TYP4	—	0.987	Q5TYP4 →
Q6ZQA0	—	0.987	Q6ZQA0 →
Q3U829	—	0.987	Q3U829 →
Q80VA5	—	0.987	Q80VA5 →
Q3TQQ9	—	0.986	Q3TQQ9 →
O15287	—	0.986	O15287 →
Q6TNU3	—	0.986	Q6TNU3 →
Q9JL70	—	0.986	Q9JL70 →
Q9D4I2	—	0.986	Q9D4I2 →
Q9H7M6	—	0.986	Q9H7M6 →
B3DIY3	—	0.986	B3DIY3 →
Q640K1	—	0.986	Q640K1 →
GCN1	Stalled ribosome sensor GCN1	0.986	landscape →
O88480	—	0.985	O88480 →
D3ZVB0	—	0.985	D3ZVB0 →
Q8C4Y3	—	0.985	Q8C4Y3 →
Q9Z0E0	—	0.985	Q9Z0E0 →
O35870	—	0.985	O35870 →
A2AKG8	—	0.984	A2AKG8 →
Q5ZIG0	—	0.984	Q5ZIG0 →
Q8C7B8	—	0.984	Q8C7B8 →
Q8WX92	—	0.984	Q8WX92 →
Q4VSN4	—	0.984	Q4VSN4 →
O43149	—	0.984	O43149 →