Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 14/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046220 | 0.90 | CFTR (0.80) | CFTR | |
| SCHEMBL19046406 | 0.89 | CFTR (0.66) | CFTRTDP1KDM4EALDH1A1 | |
| SCHEMBL19046554 | 0.89 | CFTR (0.65) | CFTRTDP1 | |
| SCHEMBL19032803 | 0.84 | CFTR (0.72) | CFTRALDH1A1 | |
| SCHEMBL19032834 | 0.83 | CFTR (0.57) | CFTRTDP1 | |
| SCHEMBL19046547 | 0.82 | CFTR (0.69) | CFTR | |
| SCHEMBL19046530 | 0.80 | CFTR (0.67) | CFTR | |
| SCHEMBL19032835 | 0.80 | CFTR (0.81) | CFTRTDP1KDM4EALDH1A1 | |
| SCHEMBL29478065 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL19032095 | 0.79 | CFTR (1.00) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4071140-B1 | CFTR REGULATORS AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-4071140-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2022-10-12 | — | — | EP | disclosed |
| WO-2017112950-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-29 | — | — | WO | disclosed |