Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19046530 | 0.90 | CFTR (0.67) | CFTRMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL19046548 | 0.90 | CFTR (0.85) | CFTRMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL19046554 | 0.89 | CFTR (0.65) | CFTRMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL19046446 | 0.87 | CFTR (0.62) | CFTRMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL19032775 | 0.84 | CFTR (0.72) | CFTRMEN1KMT2AMAPK1RAB9A | |
| SCHEMBL19046406 | 0.82 | CFTR (0.66) | CFTRKMT2AHTT | |
| SCHEMBL29478065 | 0.82 | CFTR (1.00) | CFTR | |
| SCHEMBL19032095 | 0.82 | CFTR (1.00) | CFTR | |
| SCHEMBL19046538 | 0.82 | CFTR (0.65) | CFTR | |
| SCHEMBL19032864 | 0.81 | CFTR (0.82) | CFTRMEN1KMT2AMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4071140-B1 | CFTR REGULATORS AND METHODS OF USE THEREOF | UNIV CALIFORNIA (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-4071140-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | The Regents of The University of California (US) | 2022-10-12 | — | — | EP | disclosed |
| WO-2017112950-A1 | CFTR REGULATORS AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-29 | — | — | WO | disclosed |